Circulating vitamin D concentrations and risk of breast and prostate cancer: A Mendelian randomization study. In contrast to 25(OH)D, circulating 1,25(OH)2D is generally not a good indicator of vitamin D status because it has a short half-life measured in hours, and serum levels are tightly regulated by parathyroid hormone, calcium, and phosphate [1]. Vitamin D helps regulate the renin-angiotensin-aldosterone system (and thereby blood pressure), vascular cell growth, and inflammatory and fibrotic pathways [118]. Agency for Healthcare Research and Quality. In a subsequent investigation for 4.9 years after the study's end, women who had taken the vitamin D and calcium supplements (many of whom continued to take them) had an 18% lower risk of in situ (noninvasive) breast cancer [100]. Most participants (78%) had adequate serum levels of vitamin D at baseline (at least 50 nmol/L [20 ng/mL]). J Natl Cancer Inst 2007;99:1563-5. The effect of vitamin D supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Ann Intern Med 2017;166:155-6. Philadelphia: Lippincott Williams & Wilkins, 2014. J Nutr 2018;148:712-20. Am J Clin Nutr 2004;80:1697S-705S. Silva MC, Furlanetto TW. Upon approval it will be showcased here on a random schedule. The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial. One study comparing 738 men who developed pancreatic cancer to 738 matched controls found no relationship between serum 25(OH)D levels and risk of pancreatic cancer [105]. The groups showed no significant differences in measures of muscle strength or performance [85]. Many epidemiological and genetic studies have shown an association between MS and low 25(OH)D levels before and after the disease begins [137]. No studies have evaluated whether vitamin D supplements may benefit individuals under medical care for clinical depression who have low or deficient 25(OH)D levels and are taking antidepressant medication. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. An analysis of NHANES 2009–2016 data found that only 20.5% of breastfed infants and 31.1% of infants who were not breastfed ingested these recommended amounts of supplements [61]. Endocrine Connections 2018;7:R294-303. In contrast, another meta-analysis of 30 clinical trials in 4,744 participants (mean age 54.5 years) that administered 5 mcg (200 IU) to 300 mcg (12,000 IU)/day vitamin D3 for a mean of 5.6 months showed that more than 20 mcg (800 IU)/day significantly reduced systolic and diastolic blood pressure in normal-weight participants who had hypertension [128]. Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. Vitamin D and calcium for the prevention of fracture: A systematic review and meta-analysis. Diets low in vitamin D are more common in people who have milk allergy or lactose intolerance and those who consume an ovo-vegetarian or vegan diet [1]. [, de Sevaux RGL, Hoitsma AJ, Corstens FHM, Wetzels JFM. In some cases, fortified foods and dietary supplements may be useful in providing one or more nutrients that otherwise may be consumed in less-than-recommended amounts.". Circulation 2013;128:2517-31. Circulating 25-hydroxyvitamin D concentration and risk of breast, prostate, and colorectal cancers: The Melbourne Collaborative Cohort Study. Including food 25-hydroxyvitamin D in intake estimates may reduce the discrepancy between dietary and serum measures of vitamin D status. Recommended Dietary Allowance (RDA): Average daily level of intake sufficient to meet the nutrient requirements of nearly all (97%–98%) healthy individuals; often used to plan nutritionally adequate diets for individuals. People with limited sun exposure With the D Programming Language, write fast, read fast, and run fast. [, Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. [, Taylor CL, Thomas PR, Aloia JF, Millard PS. Use of vitamin D drops leading to kidney failure in a 54-year-old man. 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